The sialic acid binding activity of the S protein facilitates infection by porcine transmissible gastroenteritis coronavirus.
Identifieur interne : 002020 ( Main/Exploration ); précédent : 002019; suivant : 002021The sialic acid binding activity of the S protein facilitates infection by porcine transmissible gastroenteritis coronavirus.
Auteurs : Christel Schwegmann-Wessels [Allemagne] ; Sandra Bauer ; Christine Winter ; Luis Enjuanes ; Hubert Laude ; Georg HerrlerSource :
- Virology journal [ 1743-422X ] ; 2011.
Descripteurs français
- KwdFr :
- Acides sialiques (antagonistes et inhibiteurs), Acides sialiques (métabolisme), Animaux, Attachement viral (), Cellules Vero, Cellules cultivées, Gastroentérite transmissible du porc (métabolisme), Gastroentérite transmissible du porc (virologie), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (), Glycoprotéines membranaires (antagonistes et inhibiteurs), Glycoprotéines membranaires (métabolisme), Liaison aux protéines (), Membrane cellulaire (), Membrane cellulaire (métabolisme), Membrane cellulaire (virologie), Mucines (pharmacologie), Mutation, Mâle, Méthode des plages virales, Oiseaux, Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (antagonistes et inhibiteurs), Protéines de l'enveloppe virale (métabolisme), Sialidase (métabolisme), Sialidase (pharmacologie), Suidae, Testicule (), Testicule (cytologie), Testicule (métabolisme), Testicule (virologie), Virion (), Virion (métabolisme), Virus de la bronchite infectieuse (métabolisme), Virus de la gastroentérite transmissible (), Virus de la gastroentérite transmissible (génétique), Virus de la gastroentérite transmissible (métabolisme), Virus de la gastroentérite transmissible (pathogénicité).
- MESH :
- antagonistes et inhibiteurs : Acides sialiques, Glycoprotéines membranaires, Protéines de l'enveloppe virale.
- cytologie : Testicule.
- génétique : Virus de la gastroentérite transmissible.
- métabolisme : Acides sialiques, Gastroentérite transmissible du porc, Glycoprotéines membranaires, Membrane cellulaire, Protéines de l'enveloppe virale, Sialidase, Testicule, Virion, Virus de la bronchite infectieuse, Virus de la gastroentérite transmissible.
- pathogénicité : Virus de la gastroentérite transmissible.
- pharmacologie : Mucines, Sialidase.
- virologie : Gastroentérite transmissible du porc, Membrane cellulaire, Testicule.
- Animaux, Attachement viral, Cellules Vero, Cellules cultivées, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Liaison aux protéines, Membrane cellulaire, Mutation, Mâle, Méthode des plages virales, Oiseaux, Protéines de l'enveloppe virale, Suidae, Testicule, Virion, Virus de la gastroentérite transmissible.
English descriptors
- KwdEn :
- Animals, Birds, Cell Membrane (drug effects), Cell Membrane (metabolism), Cell Membrane (virology), Cells, Cultured, Chlorocebus aethiops, Gastroenteritis, Transmissible, of Swine (metabolism), Gastroenteritis, Transmissible, of Swine (virology), Infectious bronchitis virus (metabolism), Male, Membrane Glycoproteins (antagonists & inhibitors), Membrane Glycoproteins (chemistry), Membrane Glycoproteins (metabolism), Mucins (pharmacology), Mutation, Neuraminidase (metabolism), Neuraminidase (pharmacology), Protein Binding (drug effects), Sialic Acids (antagonists & inhibitors), Sialic Acids (metabolism), Spike Glycoprotein, Coronavirus, Swine, Testis (cytology), Testis (drug effects), Testis (metabolism), Testis (virology), Transmissible gastroenteritis virus (drug effects), Transmissible gastroenteritis virus (genetics), Transmissible gastroenteritis virus (metabolism), Transmissible gastroenteritis virus (pathogenicity), Vero Cells, Viral Envelope Proteins (antagonists & inhibitors), Viral Envelope Proteins (chemistry), Viral Envelope Proteins (metabolism), Viral Plaque Assay, Virion (drug effects), Virion (metabolism), Virus Attachment (drug effects).
- MESH :
- chemical , antagonists & inhibitors : Membrane Glycoproteins, Sialic Acids, Viral Envelope Proteins.
- chemical , chemistry : Membrane Glycoproteins, Viral Envelope Proteins.
- cytology : Testis.
- drug effects : Cell Membrane, Protein Binding, Testis, Transmissible gastroenteritis virus, Virion, Virus Attachment.
- genetics : Transmissible gastroenteritis virus.
- metabolism : Cell Membrane, Gastroenteritis, Transmissible, of Swine, Infectious bronchitis virus, Membrane Glycoproteins, Neuraminidase, Sialic Acids, Testis, Transmissible gastroenteritis virus, Viral Envelope Proteins, Virion.
- pathogenicity : Transmissible gastroenteritis virus.
- chemical , pharmacology : Mucins, Neuraminidase.
- virology : Cell Membrane, Gastroenteritis, Transmissible, of Swine, Testis.
- Animals, Birds, Cells, Cultured, Chlorocebus aethiops, Male, Mutation, Spike Glycoprotein, Coronavirus, Swine, Vero Cells, Viral Plaque Assay.
Abstract
Transmissible gastroenteritis virus (TGEV) has a sialic acid binding activity that is believed to be important for enteropathogenicity, but that has so far appeared to be dispensable for infection of cultured cells. The aims of this study were to determine the effect of sialic acid binding for the infection of cultured cells under unfavorable conditions, and comparison of TGEV strains and mutants, as well as the avian coronavirus IBV concerning their dependence on the sialic acid binding activity.
DOI: 10.1186/1743-422X-8-435
PubMed: 21910859
Affiliations:
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Le document en format XML
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de la gastroentérite transmissible</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Membrane</term><term>Gastroenteritis, Transmissible, of Swine</term><term>Infectious bronchitis virus</term><term>Membrane Glycoproteins</term><term>Neuraminidase</term><term>Sialic Acids</term><term>Testis</term><term>Transmissible gastroenteritis virus</term><term>Viral Envelope Proteins</term><term>Virion</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acides sialiques</term><term>Gastroentérite transmissible du porc</term><term>Glycoprotéines membranaires</term><term>Membrane cellulaire</term><term>Protéines de l'enveloppe virale</term><term>Sialidase</term><term>Testicule</term><term>Virion</term><term>Virus de la bronchite infectieuse</term><term>Virus de la gastroentérite transmissible</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Transmissible gastroenteritis virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la gastroentérite transmissible</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Mucines</term><term>Sialidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Mucins</term><term>Neuraminidase</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Gastroentérite transmissible du porc</term><term>Membrane cellulaire</term><term>Testicule</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cell Membrane</term><term>Gastroenteritis, Transmissible, of Swine</term><term>Testis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Birds</term><term>Cells, Cultured</term><term>Chlorocebus aethiops</term><term>Male</term><term>Mutation</term><term>Spike Glycoprotein, Coronavirus</term><term>Swine</term><term>Vero Cells</term><term>Viral Plaque Assay</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Attachement viral</term><term>Cellules Vero</term><term>Cellules cultivées</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires</term><term>Liaison aux protéines</term><term>Membrane cellulaire</term><term>Mutation</term><term>Mâle</term><term>Méthode des plages virales</term><term>Oiseaux</term><term>Protéines de l'enveloppe virale</term><term>Suidae</term><term>Testicule</term><term>Virion</term><term>Virus de la gastroentérite transmissible</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Transmissible gastroenteritis virus (TGEV) has a sialic acid binding activity that is believed to be important for enteropathogenicity, but that has so far appeared to be dispensable for infection of cultured cells. The aims of this study were to determine the effect of sialic acid binding for the infection of cultured cells under unfavorable conditions, and comparison of TGEV strains and mutants, as well as the avian coronavirus IBV concerning their dependence on the sialic acid binding activity.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li></region><settlement><li>Hanovre</li></settlement></list><tree><noCountry><name sortKey="Bauer, Sandra" sort="Bauer, Sandra" uniqKey="Bauer S" first="Sandra" last="Bauer">Sandra Bauer</name><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name><name sortKey="Herrler, Georg" sort="Herrler, Georg" uniqKey="Herrler G" first="Georg" last="Herrler">Georg Herrler</name><name sortKey="Laude, Hubert" sort="Laude, Hubert" uniqKey="Laude H" first="Hubert" last="Laude">Hubert Laude</name><name sortKey="Winter, Christine" sort="Winter, Christine" uniqKey="Winter C" first="Christine" last="Winter">Christine Winter</name></noCountry><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Schwegmann Wessels, Christel" sort="Schwegmann Wessels, Christel" uniqKey="Schwegmann Wessels C" first="Christel" last="Schwegmann-Wessels">Christel Schwegmann-Wessels</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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